Autophagy defends cells against invading group A Streptococcus |
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| Authors: | Nakagawa Ichiro Amano Atsuo Mizushima Noboru Yamamoto Akitsugu Yamaguchi Hitomi Kamimoto Takahiro Nara Atsuki Funao Junko Nakata Masanobu Tsuda Kayoko Hamada Shigeyuki Yoshimori Tamotsu |
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| Affiliation: | Department of Oral and Molecular Microbiology, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita-Osaka 565-0871, Japan. ichiro@dent.osaka-u.ac.jp |
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| Abstract: | We found that the autophagic machinery could effectively eliminate pathogenic group A Streptococcus (GAS) within nonphagocytic cells. After escaping from endosomes into the cytoplasm, GAS became enveloped by autophagosome-like compartments and were killed upon fusion of these compartments with lysosomes. In autophagy-deficient Atg5-/- cells, GAS survived, multiplied, and were released from the cells. Thus, the autophagic machinery can act as an innate defense system against invading pathogens. |
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