C-reactive protein in the differentiation of pyometra from cystic endometrial hyperplasia/mucometra in dogs |
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Authors: | Fransson Boel A Karlstam Erika Bergstrom Annika Lagerstedt Anne-Sofie Park Jean S Evans Marc A Ragle Claude A |
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Institution: | Departments of Veterinary Clinical Sciences, Washington State University, Pullman, Washington 99164-7060, USA. |
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Abstract: | Hematological parameters, plasma C-reactive protein (CRP), and tumor necrosis factor alpha were analyzed in 64 dogs with a presumptive diagnosis of pyometra. Final diagnosis (i.e., pyometra or cystic endometrial hyperplasia CEH]) was determined by histopathology. As a single test, the percentage of band neutrophils had the highest sensitivity in the prediction of pyometra (sensitivity, 94%). The combination of percentage of bands and CRP had the highest sensitivity (97.7%; specificity, 75%) in predicting the presence of pyometra. The most common clinical signs noted in the study were vaginal discharge, polyuria, polydipsia, lethargy, and gastrointestinal signs. A combination of three or more of these clinical signs was significantly associated with pyometra. |
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