Interactions between the renin-angiotensin system and catecholamines on the cardiovascular system of elasmobranchs |
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| Authors: | M.L. Tierney K. Hamano G. Anderson Y. Takei K. Ashida N. Hazon |
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| Affiliation: | (1) Gatty Marine Laboratory, University of St Andrews, Scotland, UK;(2) National Research Institute of Fisheries Science, Yokohama, Japan;(3) Ocean Research Institute, University of Tokyo, Tokyo, Japan |
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| Abstract: | The interaction between homologous dogfish angiotensin II ([Asn1, Pro3, Ile5]-AngII) and catecholamines was examined using blood pressure bioassay. Both noradrenaline and [Asn1, Pro3, Ile5]-Ang II elicited a pressor response. Pre-treatment with phentolamine (1 mg kg-1) completely abolished the noradrenaline pressor response but did not alter the magnitude of the [Asn1, Pro3, Ile5]-Ang II pressor response although there was an initial delay in the response to [Asn1, Pro3, Ile5]-Ang II. These results indicate that the Ang II-induced pressor response is a direct Ang II-mediated vascular response in elasmobranchs. |
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| Keywords: | elasmobranch catecholamines angiotensin II cardiovascular actions |
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