| 牛腺病毒载体研究进展 |
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| 引用本文： | 邱薇,夏咸柱,范泉水,扈荣良,孙阳,杨美峰.牛腺病毒载体研究进展[J].动物医学进展,2003,24(6):11-14. |
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| 作者姓名： | 邱薇 夏咸柱 范泉水 扈荣良 孙阳 杨美峰 |
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| 作者单位： | 1. 成都军区联勤部军事医学研究所,云南昆明,650032
2. 解放军军需大学军事兽医研究所,吉林长春,130062 |
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| 摘 要： | 动物腺病毒与人腺病毒具有相似基因组结构 ,用其构建的动物腺病毒载体可将外源基因转移到人体细胞内表达 ,却又不能在其中复制繁殖 ,且人体内不存在针对它们的免疫应答 ,有望代替人腺病毒作为基因治疗和基因免疫的载体 ,目前已构建了多种动物腺病毒载体。文章综述了近年来牛腺病毒载体构建的一些研究进展。
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| 关 键 词： | 牛腺病毒 载体 基因治疗 基因免疫 |
| 文章编号： | 1007-5038(2003)06-0011-04 |
| 修稿时间： | 2003年4月23日 |
Progress on the Study of Bovine Adenovirus Vectors |
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| QIU Wei,XIA Xian-zhu,FAN Quan-shui,HU Rong-liang,SUN Yang,YANG Mei-feng.Progress on the Study of Bovine Adenovirus Vectors[J].Progress In Veterinary Medicine,2003,24(6):11-14. |
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| Authors: | QIU Wei XIA Xian-zhu FAN Quan-shui HU Rong-liang SUN Yang YANG Mei-feng |
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| Institution: | QIU Wei~1,XIA Xian-zhu~2,FAN Quan-shui~1,HU Rong-liang~2,SUN Yang~1,YANG Mei-feng~1 |
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| Abstract: | The structures of animal adenoviruses genome were similar to the human adenovirus.The vectors based on the animal adenoviruses can transform the foreign genes into the human cell and express in it, but cannot replicate in it. Furthermore there are no immune responses to them in human body. So they are hoped to replace the human adenovirus in gene therapy and gene immune. Various animal adenovirus vectors have been constructed now. The paper reviewed progress on the construction of bovine adenovirus vectors. |
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| Keywords: | bovine adenovirus vectors gene therapy gene immune |
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