| 单克隆抗体对日本血吸虫尾蚴钻穿小鼠皮肤能力的影响 |
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| 引用本文： | 叶萍,田锷,林邦发,石耀军,朱顺海,林矫矫,钟志萍.单克隆抗体对日本血吸虫尾蚴钻穿小鼠皮肤能力的影响[J].中国兽医寄生虫病,1993,1(1):30-32. |
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| 作者姓名： | 叶萍 田锷 林邦发 石耀军 朱顺海 林矫矫 钟志萍 |
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| 作者单位： | 中国农科院上海家畜寄生虫病研究所，中国农科院上海家畜寄生虫病研究所，中国农科院上海家畜寄生虫病研究所，中国农科院上海家畜寄生虫病研究所，中国农科院上海家畜寄生虫病研究所，中国农科院上海家畜寄生虫病研究所，中国农科院上海家畜寄生虫病研究所 |
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| 摘 要： | 用抗日本血吸虫单克隆抗体,在室温下与血吸虫尾蚴作用90分钟。将尾蚴分别经腹部皮肤和腹腔注射感染昆明系小鼠,4周后剖杀集虫。实验结果表明。经单克隆抗体(McAb)处理后,腹腔注射组的载虫数明显高于腹部皮肤感染组(P<0.01)。从而说明,高特异性的单克隆抗体处理能够影响尾蚴钻穿小鼠腹部皮肤的能力。
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| 关 键 词： | 单克隆抗体 日本血吸虫 尾蚴 小鼠 钻透能力 |
THE EFFECT OF MONOCLONAL ANTIBODY ON THE SKIN PENETRATING ABILITY OF THE CERCARIAE OF SCHISTOSOMA JAPONICUM IN MICE |
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| Ye Ping,Tian E,Shi Yaojun,Lin Bangfa,Zhu Shunhai,Lin Jiaojiao,Zhong Zhiping.THE EFFECT OF MONOCLONAL ANTIBODY ON THE SKIN PENETRATING ABILITY OF THE CERCARIAE OF SCHISTOSOMA JAPONICUM IN MICE[J].Chinese Journal of Veterinary Parasitology,1993,1(1):30-32. |
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| Authors: | Ye Ping Tian E Shi Yaojun Lin Bangfa Zhu Shunhai Lin Jiaojiao Zhong Zhiping |
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| Abstract: | Mice of kunming strain wera infected with cercariae of Schistosoma japonicum having been treated in vitro for 9 minutes with anti-S.japonicum monoclonal antibody (McAb) and autopsied after 4 weeks for worm recovery. The results revealed that the worm burden of the intraperi- toneally infected mice group (i.p.) is significantly higher than that of the percutaneously infec- ted mice group (p.c.)(p<0.01).This experiment showcd that the skin penetrating ability of the cercariae might be affected by their previous in vitro treatment with a McAb of class IgM produced in our laboratory. |
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| Keywords: | Schistosoma japonicum monoclonal antibody skin penetrating ability |
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