Pharmacokinetics of oral gabapentin in greyhound dogs |
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| Authors: | Butch KuKanich Rachael L Cohen |
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| Institution: | 1. Companion Labs, Inc., San Francisco, CA;2. Department of Behavior Resources, San Francisco Society for the Prevention of Cruelty to Animals, San Francisco, CA;1. Yuhan Research Institute, Yuhan Corporation, Yongin 17084, Republic of Korea;2. School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea;1. Department of Veterinary Sciences, University of Pisa, Via Livornese (lato monte) 1, San Piero a Grado, Pisa, Italy;2. College of Veterinary Medicine, Chungnam National University, Daejeon, South Korea;3. Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Italy;4. Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran;5. Veterinary School, Kostanay State A. Baitursynov University, Kostanay, Kazakhstan;6. School of Veterinary Science, The University of Queensland, Gatton Campus, Gatton, Queensland 4343, Australia;1. Department of Clinical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, North Carolina 27607;2. Department of Molecular Biomedical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, North Carolina 27607;1. Department of Physics, University of Lucknow, 226 007 Lucknow, India;2. Department of Mechatronics Engineering, H.F.T. Technology Faculty, Celal Bayar University, 45400 Turgutlu, Manisa, Turkey;3. Department of Science Education, Bayburt University, 69000 Bayburt, Turkey |
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| Abstract: | The purpose of this study was to assess the pharmacokinetics of gabapentin in healthy greyhound dogs after single oral doses targeted at 10 and 20 mg/kg PO. Six healthy greyhounds were enrolled (3 males, 3 females). Blood was obtained at predetermined times for the measurement of gabapentin plasma concentrations by liquid chromatography/mass spectrometry. Pharmacokinetic parameters were determined with computer software.The actual mean (and range) doses administered were 10.2 (9.1–12.0) mg/kg and 20.5 (18.2–24) mg/kg for the 10 mg/kg and 20 mg/kg targeted dose groups. The mean CMAX for the 10 and 20 mg/kg groups were 8.54 and 13.22 μg/mL at 1.3 and 1.5 h, and the terminal half-lives were 3.3 and 3.4 h, respectively. The relative bioavailability of the 10 mg/kg group was 1.13 compared to the 20 mg/kg group. Gabapentin was rapidly absorbed and eliminated in dogs, indicating that frequent dosing is needed to maintain minimum targeted plasma concentrations. |
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