A model for the preferential delivery of isoflurane to the spinal cord of the goat |
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| Authors: | Jing Yang Zhuo Li Chun-Yu Gong Yun-Fei Chai Tao Li Guo-Hua Li Nan Luo Nan-Fu Luo Lei Zhu Jin Liu |
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| Affiliation: | 1. Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, China;2. Department of Intensive Care Unit, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, China;3. Department of Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;1. Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, PR China;2. Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, PR China |
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| Abstract: | To identify the blood supply of the caprine central nervous system, six anaesthetised goats were perfused with coloured suspension into the brachiocephalic artery, the aorta, the iliac artery and the femoral artery. The subsequent distribution indicated that the brain and the main segments of the spinal cord were supplied by the brachiocephalic artery and aorta, respectively. Ten similarly anaesthetised goats then received emulsified isoflurane randomly via either the proximal part of the descending aorta (arterial group) or an ear vein (venous group). In the arterial group, the isoflurane partial pressure (Piso) in femoral arterial blood was almost double the Piso in jugular venous blood. The model showed that preferential delivery of isoflurane to the goat spinal cord in situ was possible and could be used for further research into the mechanisms of anaesthetic action, particularly factors affecting immobility. |
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