| 栝楼根提取物抗肿瘤作用初探 |
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| 引用本文： | 吴红军,吴国娟,沈红,稻富秀夫,长泽弘. 栝楼根提取物抗肿瘤作用初探[J]. 动物医学进展, 2006, 27(6): 99-102 |
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| 作者姓名： | 吴红军 吴国娟 沈红 稻富秀夫 长泽弘 |
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| 作者单位： | 北京农学院动物科学技术系,北京,102206;新疆农业大学动物医学学院,新疆乌鲁木齐,830052;北京农学院动物科学技术系,北京,102206;日本东京明治大学农学院,日本东京 |
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| 摘 要： | 为探究栝楼根提取物的药理作用，通过体外细胞毒性试验和动物试验观察栝楼根提取物对肿瘤的影响。细胞毒性试验表明栝楼根提取物在0．5mg／mL以上浓度时明显抑制小鼠骨髓瘤细胞（SP2／0）的生长；动物试验表明栝楼根提取物在0．1mg／mL注射剂量时肿瘤抑制效果最佳，抑制率可达40．9％。
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| 关 键 词： | 栝楼根提取物 抗肿瘤 有效成分 |
| 文章编号： | 1007-5038（2006）06-0099-04 |
| 收稿时间： | 2006-02-24 |
| 修稿时间： | 2006-02-24 |
Study on Anti-cancer Effects of Extract from Trichosanthes |
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| CHE Yong-liang , WANG Long-bai , WEI Hong , ZHOU Lun-jiang , ZHUANG Xiang-sheng , CHENG Shao-ying. Study on Anti-cancer Effects of Extract from Trichosanthes[J]. Progress In Veterinary Medicine, 2006, 27(6): 99-102 |
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| Authors: | CHE Yong-liang WANG Long-bai WEI Hong ZHOU Lun-jiang ZHUANG Xiang-sheng CHENG Shao-ying |
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| Affiliation: | 1. Institute of Animal Husbandry and Veterinary Medicine, Fujian Academy of Agriculture Sciences, Fuzhou, Fujian, 350013, China ; 2. Fujian Animal Diseases Control Technology Development Center , Fuzhou, Fujian , 350013 , China |
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| Abstract: | In order to probe into the effective component of the Trichosanthes in pharmacology,we do MTT and animal test to research its effect on tumor.The results showed that the growth of the SP2/0 cells was obviously inhibited above the concentration of 0.5 mg/mL in vitro and that the growth of Balb/c mice tumor was significantly inhibited with the concentration of 0.1 mg/mL in vivo.The restraint rate achieved 49%. |
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| Keywords: | extract of Trichosanthes anticancer active ingredient |
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