Stimulation of phospholipase C-gamma 1 membrane association by epidermal growth factor |
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| Authors: | G Todderud M I Wahl S G Rhee G Carpenter |
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| Institution: | Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232-0146. |
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| Abstract: | Epidermal growth factor (EGF) treatment of A-431 epidermoid carcinoma cells elicited a redistribution of phospholipase C-gamma 1 (PLC-gamma 1) from a predominantly cytosolic localization to membrane fractions. The temporal coincidence of this redistribution with EGF stimulation of inositol phosphate formation and EGF increased phosphorylation of PLC-gamma 1 suggests that the membrane association of PLC-gamma 1 is a significant event in second messenger transduction. |
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