| 披针叶黄华生物碱的毒性试验研究 |
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| 引用本文： | 李勇,魏彦明,石雅芳.披针叶黄华生物碱的毒性试验研究[J].动物医学进展,2016(11):78-82. |
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| 作者姓名： | 李勇 魏彦明 石雅芳 |
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| 作者单位： | 1. 甘肃农业大学动物医学院，甘肃兰州 730070; 宁夏职业技术学院生命科学技术系，宁夏银川 750021;2. 甘肃农业大学动物医学院,甘肃兰州,730070;3. 宁夏农业学校,宁夏银川,750021 |
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| 基金项目： | 宁夏高等学校科学研究项目(NGY2016251) |
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| 摘 要： | 通过披针叶黄华碱对小鼠毒性试验的研究,复制出喹喏里西啶类生物碱中毒病理学模型。结果表明,小鼠一次性灌服总碱200mg/kg时,即出现急性中毒死亡,由此大致推断其LD50≤200mg/kg;对慢性中毒小鼠的血液生化检查中发现,披针叶黄华碱可使小鼠体内血红蛋白、红细胞、白细胞数量升高,谷丙转氨酶(ALT)、谷草转氨酶(AST)、肌酸激酶(CK)含量升高,尿素氮(BUN)浓度下降;对慢性中毒小鼠的临床病理学检查中发现,以心、肝、肺、肾实质器官的细胞变性坏死为主,尤其是以肝脏、肾脏的损伤较为严重,也说明披针叶黄华碱毒性作用的靶器官可能是肝脏和肾脏。
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| 关 键 词： | 披针叶黄华碱 毒性 试验 |
Study on Toxicity of Alkaloids of Thermopsis lanceolata |
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| Abstract: | The aim of the paper was to study the toxicity of alkaloids of Thermopsis lanceolata and copy out here in quinolizidine poisoning pathology model.The results showed that mice drenched with 200 mg/kg of alkaloids from Thermopsis lanceolata were all dead.As results,LD50 was less than 200 mg/kg.Blood bio-chemical examination of chronic intoxication in mice found that alkaloids of Thermopsis lanceolata in-creased HGB,RBC,WBC,ALT,AST and CK,but decreased BUN.The cells in heart,liver,kidney were appeared degeneration and necrosis,especially in liver and kidney,these two organs are the target organs. |
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| Keywords: | alkaloid of Thermopsis lanceolata toxicity test |
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