单端孢霉烯族毒素抑制动物生长作用的研究进展

单端孢霉烯族毒素是主要的饲料污染物,包括T-2毒素、脱氧雪腐镰刀菌烯醇(DON)等,具有较强的毒性作用,能引起动物体多种病理变化。其毒性作用能改变真核翻译起始因子2α(EIF2α)、丝裂原激活的蛋白激酶(MAPK)、热休克蛋白90(Hsp90)、胰岛素样生长因子1(IGF-1)等细胞因子的活性,调节多种胺酰tRNA合成酶的活性,进而抑制蛋白质合成,阻滞动物生长。论文从单端孢霉烯族毒素对生长激素影响的角度,综述了该类毒素对动物生长的抑制作用,以期为阐明单端孢霉烯族毒素抑制动物生长的毒性作用机制奠定基础。

Progress on Growth Inhibition of Trichothecenes in Animals

Trichothecenes,mainly feed contaminants,include T-2 toxin,deoxynivalenol (DON)and so on. With a strong toxicity,they can cause a varieties of pathological lesionses in animals.Trichothecenes can in-hibit the synthesis of protein via changing the activation of some substances,such as eukaryotic translation initiation factor 2α(EIF2α),mitogen-activated protein kinase (MAPK),heat shock protein HSP 90-beta (Hsp90)and insulin like growth factor 1 (IGF-1)and regulating activation of several aminoacyl-tRNA synthetase,and eventually cause growth retardation in animals.In terms of the toxicity effect on growth hormone,this review summarized the inhibition induced by trichothecenes,with the purpose of laying the foundation for illuminating the mechanism of growth inhibition.