MicroRNA调控胚胎植入研究进展

植入是胚胎与子宫内膜识别、接触并依附于子宫内膜上或进一步侵入、包埋于子宫内膜中的过程,是哺乳动物生殖生理的重要环节,这一过程对于胚胎能够在子宫持续的发育并最终获得成功的妊娠是必需的。成功的植入需要同步发育的正常胚胎、容受性的子宫内膜及母胎的和谐对话来实现。胚胎植入过程复杂而短暂,参与调控的因素有很多,包括microRNA。论文介绍了与植入相关microRNA的最新研究进展,包括microRNA对胚胎发育、子宫内膜的容受性等方面的作用,将为我们理解植入机制提供新的视角。

Progress on MicroRNA in Regulation of Embryo Implantation

Implantation is a process which animal blastocyst and endometrium recognize,contacts,and at-tach to the endometrium or further invade and embedd in the endometrium.This process is an important part of the mammalian reproductive physiology and it is essential to continued embryonic development within the uterus for achieving successful pregnancy.Synchronized development of the embryo to the ac-tive stage of the blastocyst,differentiation of the uterus to the receptive state,and a harmonious crosstalk between the blastocyst and uterine luminal epithelium are essential to a successful implantation process. Embryo implantation process is complicated and short,there are many factors involved in the implantation regulation,including microRNA.In this article,we introduced the latest research progress on microRNA in the regulation of embryo implantation,including the role of microRNA in embryo development,endom-etrial receptivity,and so on.It will provide a new perspective on our understanding of implantation mecha-nism.