Three new phenolic glycosides from Curculigo orchioides G. |
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| Authors: | Ai-Xue Zuo Yong Shen Zhi-Yong Jiang Xue-Mei Zhang Jun Zhou Jun Lü Ji-Jun Chen |
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| Institution: | 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan 650204, China;2. Kunming Jingbiao Biosciences RD Co. Ltd., Kunming, Yunnan, 650000, China;3. Graduate University of Chinese Academy of Sciences, Beijing 100039, China |
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| Abstract: | Three new phenolic glycosides, curculigosides F–H (1–3), were isolated from rhizomes of Curculigo orchioides Gaertn. Their structures were elucidated based on comprehensive spectroscopic analyses including IR, MS, 1D- and 2D NMR (HSQC, COSY, and HMBC). Curculigosides F–H (1–3) were evaluated for their anti-HBV activity in vitro using the HBV transfected Hep G2.2.15 cell line. Compound 1 exhibited weak activity with an IC50 value of 2.08 mM on hepatitis B virus (HBV) e antigen (HBeAg) secretion of the HepG2.2.15 cell line. |
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| Keywords: | Curculigosides F&ndash H Phenolic glycoside Anti-HBV Curculigo orchioides |
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