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Antibacterial sideroxylonals and loxophlebal A from Eucalyptus loxophleba foliage |
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| Authors: | Jasmeen Sidana Rajesh K. Rohilla Nilanjan Roy Russell A. Barrow William J. Foley Inder Pal Singh |
| Affiliation: | 1. Department of Natural Products, National Institute of Pharmaceutical Education and Research (NIPER), Sector-67, S.A.S. Nagar, Punjab-160062, India;2. Department of Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER), Sector-67, S.A.S. Nagar, Punjab-160062, India;3. Research School of Chemistry, The Australian National University, Canberra 0200, Australia;4. Research School of Biology, The Australian National University, Canberra 0200, Australia |
| Abstract: | Loxophlebal A, a new antibacterial formylated phloroglucinol was isolated from the mother liquor obtained after separation of sideroxylonals from the chloroform–methanol extract of leaves of Eucalyptus loxophleba ssp lissophloia. The structure of loxophlebal A was determined to be 3-desformyl sideroxylonal A by spectroscopic methods including 1D- and 2D-NMR. The stereochemistry of loxophlebal A was determined by chemical correlation with sideroxylonal A. This article also reports an efficient, simple and economic method for large scale isolation of sideroxylonals in a purity of > 90% from the leaves of Eucalyptus loxophleba ssp lissophloia. |
| Keywords: | Eucalyptus loxophleba Sideroxylonals Loxophlebal A Large scale isolation Antibacterial |
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