瑞香狼毒根对长爪沙鼠的急性毒力测试

本文采用含17%瑞香狼毒(Stellera chamaejasme)根粉末的毒饵,依据孙氏改良寇氏综合计算法,实验室内测定了其对长爪沙鼠(Meriones unguiculatus)的急性毒力。根据预试验结果,采用最低剂量为7.0 g·kg^-1,最适剂量梯度比值K=0.65的5个剂量梯度的瑞香狼毒根毒饵饲喂长爪沙鼠。结果显示:试验组试鼠体重明显下降(P=0.029<0.05),完全致死组肝脏重/体重比对照组明显减小(P=0.014<0.05),但肾脏略增大(P=0.102>0.05)。其对长爪沙鼠的LD50为(20.37±0.086)g·kg^-1,95%平均可信限为(20.37±7.84)g·kg^-1,属弱毒水平。

Acute Toxicity Analyses of Stellera chamaejasme Root in Mongolian Gerbils(Meriones unguiculatus)

Both whole Stellera chamaejasme and its extract are demonstrated to have powerful toxicity to some pest insects.The poison bait containing 17% roots of Stellera chamaejasme was used to test the acute toxicity of Stellera chamaejasme in Mongolian gerbils according to Sun′s improved Kou′s Integrated Way.Mongolian gerbils were treated with 5 treatments of toxicant bait according to pretested results: the lowest dose was 7.0 g/kg and the optimal gradient dose radio was 0.65.Results indicate that the body weight of treatment group was significantly decreased as compared to control(P=0.029<0.05).The rate of liver to body weight was significantly decreased in groupⅤ(P=0.014<0.05,whereas,the percent of kidney to body weight was slightly increased in groupⅤ(P=0.102>0.05) compared with controls.The LD₅₀ of Stellera chamaejasme in Mongolian gerbils is 20.37±0.086 g/kg.The confidence limit on 95% is(20.37±7.84) g/kg.The acute virulence is slight as relates to the graded standard of toxicant against mice.