Factors associated with outcome in foals with neonatal isoerythrolysis (72 cases, 1988-2003) |
| |
Authors: | Polkes A C Giguère S Lester G D Bain F T |
| |
Affiliation: | Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL;;School of Veterinary and Biomedical Sciences, Murdoch University, WA;and;Hagyard Equine Medical Institute, Lexington, KY |
| |
Abstract: | Background: Neonatal foals with isoerythrolysis (NI) often die, but the risk factors for death have not been identified. Objectives: To identify factors associated with outcome in foals with NI and to identify factors associated with death from liver failure or kernicterus in the same population. Animals: Seventy-two foals with NI examined at referral institutions. Methods: Retrospective case series. Information on signalment, clinical examination findings, laboratory testing, treatment, complications, outcome, and necropsy results were obtained. Results: The overall survival rate was 75% (54 of 72). Liver failure (n = 7), kernicterus (n = 6), and complications related to bacterial sepsis (n = 3) were the 3 most common reasons for death or euthanasia. The number of transfusions with blood products was the factor most strongly associated with nonsurvival in a multivariate logistic regression model. The odds of liver failure developing in foals receiving a total volume of blood products ≥ 4.0 L were 19.5 (95% confidence intervals [CI]: 2.13–178) times higher than that of foals receiving a lower volume ( P = .009). The odds of kernicterus developing in foals with a total bilirubin ≥ 27.0 mg/dL were 17.0 (95% CI: 1.77–165) times higher than that of foals with a lower total bilirubin ( P = .014). Conclusions and Clinical Importance: Development of liver failure, kernicterus, and complications related to bacterial sepsis are the most common causes of death in foals with NI. Foals administered a large volume of blood products are at greater risk for developing liver failure. |
| |
Keywords: | Anemia Bilirubin Blood transfusion Kernicterus Liver failure |
本文献已被 PubMed 等数据库收录! |
|