Five novel naphthylisoquinoline alkaloids with growth inhibitory activities against human leukemia cells HL-60, K562 and U937 from stems and leaves of Ancistrocladus tectorius |
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| Affiliation: | 1. Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China;2. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China;3. School of Life Science & Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, PR China;4. Department of Pharmacy, Hainan Medical College, Haikou 571101, PR China;5. Mount Sinai School of Medicine, New York, NY 10029, USA;1. Division of Functional Pathology, Department of Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan;2. Department of Dentistry and Oral Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan;1. University of Oklahoma Health Sciences Center, Oklahoma City;2. Georgia Cancer Specialists, Atlanta;3. SCRI, Tennessee Oncology, PLLC, Nashville;4. Arqule, Inc., Woburn;5. BioMarin Pharmaceutical, Inc., Novato;6. St Luke''s Medical Center, Houston, USA;1. Clinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt;2. Medical Oncology Unit, Internal Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt |
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| Abstract: | Two new 7,6′-coupled naphthylisoquinolines, namely ancistrotectorines A (1) and B (2), two new 5,3′-coupled naphthylisoquinolines, namely ancistrotectorines C (3) and D (4), and one new 7,8-coupled naphthylisoquinoline, namely ancistrotectorine E (5), together with 9 known naphthylisoquinoline alkaloids, hamatine (6), ancistrobertsonine B (7), ancistrocladinine (8), hamatinine (9), ancistrotanzanine A (10), ancistrotanzanine B (11), ancistrotectoriline B (12), 7-epi-ancistrobrevine D (13), and ancistrotectorine (14), were isolated from the 70% EtOH extract of Ancistrocladus tectorius. Their structures were elucidated based on the extensive analysis of spectroscopic data (1D, 2D NMR and MS). Compound 5 exhibited inhibitory activities against HL-60, K562 and U937 cell lines with IC50 values of 1.70, 4.18 and 2.56 μM respectively. |
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