A review on indole alkaloids isolated from Uncaria rhynchophylla and their pharmacological studies |
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| Institution: | 1. Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, 88 Yuquan Road, Tianjin 300193, PR China;2. Tianjin International Joint Academy of Biotechnology and Medicine, Tianjin, 300457, PR China;3. Institute of Scientific and Technological Research (IRST), P.O. Box: 227, Rwanda;2. Departments of Biochemistry, The Children''s Hospital at Westmead, Sydney, NSW 2145, Australia;1. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;2. Institute of Materia Medica, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing 100050, China;1. Atta-ur-Rahman Institute for Natural Product Discovery, Universiti Teknologi MARA, Selangor, Malaysia;4. Faculty of Applied Sciences, Universiti Teknologi MARA, Selangor, Malaysia;1. College of Pharmacy, College (Institute) of Integrative Medicine, The National & Local Joint Engineering Research Center for Drug Development of Neurodegenerative Disease, Dalian Medical University, Dalian, China.;2. Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Department of Natural Products Chemistry, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China;3. Institute of Functional Materials and Molecular Imaging, College of Emergency and Trauma, Hainan Medical University, Haikou, China |
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| Abstract: | Uncaria rhynchophylla (Miq.) Jacks, Rubiaceae, is one of the original plants of the important Chinese crude drug, Gou-teng, mainly used for the treatment of convulsion, hypertension, epilepsy, eclampsia, and cerebral diseases. The pharmacological activities of this plant are related to the presence of active compounds predominantly indole alkaloids. In this article, we have reviewed some reports about the pharmacological activities of the main indole alkaloids isolated from U. rhynchophylla. This review paper will contribute to the studies on the chemistry, safety and quality control of medicinal preparations containing Uncaria species. |
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