Isolation and identification of a new anti-inflammatory cyathane diterpenoid from the medicinal fungus Cyathus hookeri Berk |
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| Affiliation: | 1. School of Business Administration, Shenyang Pharmaceutical University, Shenyang 110016, PR China;2. Center for Drug Evaluation, SFDA, 1 Fuxing Road, Beijing 100038, PR China;3. State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, No. 9 Beiertiao, Zhongguancun, Haidian District, Beijing 100190, PR China;4. College of Life Science, Southwest Forestry University, Kunming 650224, PR China;1. Xiangya Hospital, Central South University, Changsha 410008, China;2. School of Pharmaceutical Sciences, Central South University, Changsha 410013, China;3. Hunan Xinhui Pharmaceutical Co., Ltd., Changsha 410200, China;4. Haikou People''s Hospital, Haikou 570208, China |
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| Abstract: | A new cyathane diterpene, named as cyathin I (1), as well as two known cyathane diterpenes (12R)-11a,14a-epoxy-13a,14b,15-trihydroxycyath-3-ene (2) and erinacine I (3), were isolated from the liquid culture of Cyathus hookeri Berk. Their structures were elucidated on the basis of extensive spectroscopic analysis. Compounds 1–3 showed inhibition against nitric oxide production in macrophages with an IC50 value of 15.5, 52.3, and 16.8 μM, respectively. |
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