Coreosides A–D,C14-polyacetylene glycosides from the capitula of Coreopsis tinctoria and its anti-inflammatory activity against COX-2 |
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| Institution: | 1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, No. 38 Xueyuan Road, Beijing 100191, PR China;2. Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, PR China;1. Laboratory of Pharmaceutical Analysis and Drug Metabolism, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Science, Zhejiang University, Hangzhou 310058, China;2. College of Food Sciences and Pharmacy, Xinjiang Agricultural University, Xinjiang 830052, China;1. Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, Chinese Academy of Sciences, Datun Road No. 15, Chaoyang District, Beijing, China;2. Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnosis, School of Pharmacy, Tianjin Medical University, Tianjin 300070, China;3. Department of Pharmacognosy, College of Pharmacy, Jiamusi University, Jiamusi 154007, China;4. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China;1. Laboratory of Pharmaceutical Analysis and Drug Metabolism, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Science, Zhejiang University, Hangzhou 310058, China;2. College of Food Sciences and Pharmacy, Xinjiang Agricultural University, Xinjiang 830052, China;3. Research Center of Siyuan Natural Pharmacy and Biotoxicology, College of Life Sciences, Zhejiang University, Hangzhou 310058, China |
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| Abstract: | Four new C14-polyacetylene glycosides, namely coreosides A–D (1–4), were isolated from the capitula of Coreopsis tinctoria, a Snow chrysanthemum or Snow tea that is used as a folk tea for prevention of cardiovascular disease in southern Xinjiang, China. Coreosides A–D feature a long chain structure as its aglycon with two acetylenes on C-8 and C-10 and two olefinics on C-6 and C-12 sites, which construct a large conjugate system. The structures were elucidated on the basis of spectroscopic evidences and hydrolysis. Compounds 1–4 exhibited significant inhibition against cyclooxygenase-2 at the concentration of 1 × 10? 6 mol/L, with its IC50 values of 0.22–8.8 × 10? 2 μmol/L. |
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