Xanthone derivatives from the fermentation products of an endophytic fungus Phomopsis sp. |
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| Institution: | 1. Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan University of Nationalities, Kunming 650031, PR China;2. Clinical Laboratory, First People''s Hospital of Yunnan Province, Kunming 650032, PR China;1. Institute of Traditional Chinese Medicine & Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China;2. State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210023, China;3. Clinical Experimental Center, First Affiliated Hospital of Jinan University, Guangzhou 510632, China;1. The United Graduate School of Agricultural Sciences, Iwate University, Morioka, Iwate 020-8550, Japan;2. Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata 997-8555, Japan;3. Graduate School of Arts and Sciences, Iwate University, Morioka, Iwate 020-8550, Japan;1. Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University Düsseldorf, Universitätsstrasse 1, Düsseldorf 40225, Germany;2. Department of Organic Chemistry, Higher Teachers'' Training College, University of Yaounde I, P. O. Box 47, Yaounde, Cameroon;3. Institute of Inorganic and Structural Chemistry, Heinrich-Heine-University Düsseldorf, Universitätsstrasse 1, Düsseldorf 40225, Germany;4. State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China |
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| Abstract: | Three new xanthones, 1,5-dihydroxy-3-hydroxyethyl-6-methoxycarbonylxanthone (1), 1-hydroxy-5- methoxy-3-hydroxyethyl-6-methoxycarbonylxanthone (2), and 1-hydroxy-3-hydroxyethyl- 8-ethoxycarbonylxanthone (3), along with seven known xanthones (4–10) were isolated from the fermentation products of an endophytic fungus Phomopsis sp.. Their structures were elucidated by spectroscopic methods including extensive 1D- and 2D-NMR techniques. Compounds 1–10 were also tested for their cytotoxicity against five human tumor cell lines (NB4, A549, SHSY5Y, PC3, and MCF7) by MTT method using paclitaxel as positive control. Compounds 1 and 3 showed cytotoxicity against A549 cell lines with IC50 values of 3.6 and 2.5 μM, respectively. In addition, 1 was cytotoxic to MCF7 cells with IC50 value of 2.7 μM. |
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