A new cytotoxic cembrane diterpene from the roots of Euphorbia pekinensis Rupr |
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| Institution: | 1. The Engineering Laboratory of National and Local Union of Quality Control for Traditional Chinese Medicine, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, PR China;2. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, PR China;1. College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, China;2. College of Pharmacy, Harbin University of Commerce, Harbin 150076, China;3. School of Medicine, Nankai University, Tianjin 300071, China;4. Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai 980-8578, Japan |
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| Abstract: | A new cembrane diterpene, named (−)-(1S)-15-hydroxy-18-carboxycembrene, was isolated from petroleum ether extract of the roots of the Euphorbia pekinensis Rupr. To our knowledge, this compound is the first cembrane-type diterpenoid to be found in the family Euphorbiaceae. The structure was elucidated as (−)-(1S)-15-hydroxy-cembra -2E, 4Z, 7E, 11E-tetraen-18-oic acid by a combination of IR, HR-ESIMS, 1D- and 2D-NMR techniques. (−)-(1S)-15-hydroxy-18-carboxycembrene showed cytotoxic activity against all five human cancer cell lines tested. |
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