Quinolone alkaloids with antibacterial and cytotoxic activities from the fruits of Evodia rutaecarpa |
| |
| Institution: | 1. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, People''s Republic of China;2. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, People''s Republic of China;3. Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, People''s Republic of China;4. Institute of Medicinal Biotechnology Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, People''s Republic of China;1. Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, People''s Republic of China;2. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, People''s Republic of China;3. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, People''s Republic of China;1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China;2. Research Studio of Integration of Traditional and Western Medicine, First Hospital, Peking University, Beijing 100034, China |
| |
| Abstract: | Five new quinolone alkaloids, euocarpines A–E (16–20), four new natural products (1, 4, 12, and 14), and eleven known natural products were isolated from the fruits of Evodia rutaecarpa (Juss.) Benth. The structures of the new compounds were elucidated based on spectroscopic evidence. All compounds were evaluated for their antibacterial activity against three strains and for their cytotoxic activity against four human tumor cell lines. The results revealed that 5, 7–11, 13, 14, and 16–20 exhibited moderate antibacterial activities (MIC values: 4–128 μg/mL), and 9, 11, 14, and 17 exhibited moderate cytotoxic activities against HepG-2, Hela, BEL7402, and BEL7403 (IC50 values: 15.85–56.36 μM). |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
