Pestaloficiols Q–S from the plant endophytic fungus Pestalotiopsis fici |
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| Institution: | 1. State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, PR China;2. Beijing Institute of Pharmacology & Toxicology, Beijing 100850, PR China;1. Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, TU Dortmund, Otto-Hahn-Str. 6, D-44221 Dortmund, Germany;2. Julius Kühn Institute, Federal Research Centre for Cultivated Plants, Institute for National and International Plant Health, Messeweg 11-12, D-38104 Braunschweig, Germany;3. Department of Organic Chemistry, Faculty of Science, University of Yaoundé 1, P.O. Box 812, Yaoundé, Cameroon;1. Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University Düsseldorf, Universitätsstrasse 1, Düsseldorf 40225, Germany;2. Department of Organic Chemistry, Higher Teachers'' Training College, University of Yaounde I, P. O. Box 47, Yaounde, Cameroon;3. Institute of Inorganic and Structural Chemistry, Heinrich-Heine-University Düsseldorf, Universitätsstrasse 1, Düsseldorf 40225, Germany;4. State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China;1. State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, China;2. Program for Natural Products Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China |
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| Abstract: | Two new isoprenylated chromone derivatives, pestaloficiols Q (1) and R (2), and one new benzofuran derivative, pestaloficiol S (3), along with three known metabolites, anofinic acid (4), siccayne (5), and pyrenophorol (6) were isolated from solid cultures of the plant endophytic fungus Pestalotiopsis fici. Their structures were elucidated primarily by NMR spectroscopy, and the absolute of the C-6 secondary alcohol in 1 was deduced on the basis of circular dichroism (CD) data. Compound 5 showed cytotoxic activity against the human cancer cell lines, HeLa and HT29, with IC50 values of 48.2 and 33.9 μM, respectively. |
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