Bioassay-guided isolation of urease and α-chymotrypsin inhibitory constituents from the stems of Lawsonia alba Lam. (Henna) |
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| Institution: | 1. Department of Biochemistry, Faculty of Agriculture, Fayoum University, Fayoum 63514, Egypt;2. Microbiology and Immunology Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62514, Egypt;3. Molecular Microbiology Department, The John Innes Center, Norwich Research Park, Norwich NR4 7UH, UK;4. ICBAS-Instituto de Ciências Biomédicas Abel Salazar and CIIMAR, Universidade do Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal;5. Department of Metabolic Biology & Biological Chemistry, The John Innes Center, Norwich Research Park, Norwich NR4 7UH, UK;6. Organic Chemistry Division, Department of Chemistry, Faculty of Sciences, Mansoura University, Mansoura 35516, Egypt |
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| Abstract: | Seven constituents were isolated from the stems of Lawsonia alba Lam., following an activity-guided isolation, which include two new constituents, namely lawsorosemarinol (1) and lawsofructose (2), one known compound 2-(β-d-glucopyranosyloxy)-1, 4-naphthoquinone (3) and four compounds, 4-hydroxy coumarine (4), 3-(4-hyroxyphenyl)-triacontyl-(Z)-propenoate (5), 3-(4-hydroxy-3-methoxyphenyl)-triacontyl-(Z)-propenoate (6) and 7-hydroxy-4-methyl coumarin (7) first time isolated from Lawsonia alba. Their structure elucidation was based on spectroscopic data analyses. Compounds 3 and 7 showed a moderate inhibition of urease activity, while rest of them showed less than 50% inhibition. These compounds did not show any significant inhibition against α-chymotrypsin. |
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