Anti-neuroinflammatory constituents from Asparagus cochinchinensis |
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| Affiliation: | 1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, China;2. Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China;1. College of Life Sciences, Henan Normal University, Xinxiang 453007, Henan, PR China;2. School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, Henan, PR China;3. Institute of Food Corps, Hubei Academy of Agricultural Sciences, Wuhan 430064, Hubei, PR China;1. Department of Applied Biological Science, Faculty of Agriculture, Kagawa University, Miki, Kagawa 761-0795, Japan;2. Department of Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku, Yokohama 223-8522, Japan;1. State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China;2. Pôle Actifs Végétaux, Institut de Recherche Pierre Fabre, 3 avenue Hubert Curien, 31035 Toulouse Cedex 1, France;3. USR CNRS-Pierre Fabre No. 3388 ETaC, Centre de Recherche et Développement Pierre Fabre, 3 avenue Hubert Curien, 31035 Toulouse Cedex 01, France;1. Botany and Microbiology Department, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia;2. Plant Production Department, College of Food and Agriculture Sciences, King Saud University, Riyadh, Saudi Arabia;3. Floriculture, Ornamental Horticulture and Garden Design Department, Faculty of Agriculture (El-Shatby), Alexandria University, Alexandria, Egypt;4. Department of Geography, Environmental Management and Energy Studies, University of Johannesburg, Auckland Park Kingsway Campus (APK) Campus, 2006, South Africa |
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| Abstract: | Three new pregnane glycosides, aspacochinosides N (1), O (2), and P (3) were isolated from the roots of Asparagus cochinchinensis, together with four known furostanol glycosides. Their structures were determined by chemical methods and NMR spectral analysis, including extensive 1D and 2D NMR experiments. Compounds 1–7 were evaluated for their anti-neuroinflammatory activity in LPS-induced BV-2 microglial cells. Compounds 2, 3, and 4 showed significant inhibition on NO production in LPS-induced BV-2 microglial cells with IC50 values of 13.51, 4.72, and 63.57 μM, respectively. |
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