Bioactive carbazole alkaloids from Murraya koenigii (L.) Spreng |
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| Institution: | 1. Department Chemie, Technische Universität Dresden, Bergstraße 66, 01069 Dresden, Germany;2. Institute for Tuberculosis Research, College of Pharmacy, University of Illinois at Chicago, 833 S. Wood St., MC 964, Chicago, IL 60612-7231, USA;1. Department of Graduate Students, College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang 473061, China;2. Department of Pharmacology, College of Pharmacy, China Pharmaceutical University, Nanjing 210009, China;3. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;1. Department of Biochemistry and Molecular Biology, Egerton University, Njoro Campus, PO Box, 536 – 20115, Egerton, Kenya;2. Department of Biochemistry and Biotechnology, School of Pure and Applied Sciences, Kenyatta University, Ruiru Campus, PO Box, 43844-00100, Nairobi, Kenya;3. Department of Chemistry, School of Pure and Applied Sciences, Kenyatta University, Ruiru Campus, PO Box, 43844-00100, Nairobi, Kenya;4. International Centre of Insect Physiology and Ecology (icipe), Duduville Campus, Kasarani, PO Box, 30772-00100, Nairobi, Kenya;5. Centre for Geographic Medicine Research - Coast, Kenya Medical Research Institute, PO Box, 230-80108, Kilifi, Kenya;6. Biotechnology Research Institute - Kenya Agricultural and Livestock Research Organization, PO Box, 362-00902, Kikuyu, Kenya;1. State Key Laboratory of Innovative Drugs and High Efficiency Energy Saving and Consumption Reduction Pharmaceutical Equipment, Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Key Laboratory of Modern Preparation of TCM of Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004, China;2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China |
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| Abstract: | Four new carbazole alkaloids (1–4) and fourteen known carbazole alkaloids (5–18) were isolated from Murraya koenigii. Their structures were elucidated on the basis of extensive spectroscopic analysis. Compounds 4, 6, 16, and 17 (10 μM) had moderate hepatoprotective activities against d-galactosamine-induced HL-7702 cell damage. Compounds 11, 12 and 18 showed significant PTP1B inhibitory activity with IC50 values of 1.773, 1.875 and 2.286 μM, respectively. |
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