Pharmacokinetics of puerarin in pregnant rats at different stages of gestation after oral administration |
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| Institution: | 1. College of Pharmaceutical Science, Soochow University, Suzhou, 215123, China;2. Pharmaceutical preparation section, Suzhou Municipal Hospital, Suzhou, 215001, China;3. College of Pharmacy, Ajou University, Suwon, 443-749, Republic of Korea;1. State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beisanhuan East Road 15#, Beijing 100029, China;2. State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beisanhuan East Road 15#, Beijing 100029, China;3. College of Materials Science and Engineering, Beijing University of Chemical Technology, Beisanhuan East Road 15#, Beijing 100029, China;1. Shandong Shengli Bioengineering Co., LTD., Jining 272000, Shandong, China;2. Faculty of Materials Science and Chemical Engineering, State Key Laboratory Base of Novel Functional Materials and Preparation Science, Ningbo University, Ningbo 315211, China |
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| Abstract: | This study aims to observe the effects of gestational stage on the pharmacokinetics of puerarin after oral administration in rats. The pharmacokinetics of puerarin was studied in pregnant rats using a sensitive and reproducible high-performance liquid chromatography/ultraviolet method. The concentration–time curves in both normal and pregnant rats were fit into a two-compartment model. The results indicated that gestation influences the pharmacokinetics of puerarin at different levels, especially during the early stages of pregnancy. Furthermore, puerarin penetrates the placental barrier and maintains high concentrations in fetal rat plasma. Therefore, puerarin administration should be carefully considered in pregnant women. |
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