Four new coumarinolignoids from seeds of Solanum indicum

Activity-guided fractionation of seeds of Solanum indicum for anti-HBV activity led to the isolation of two novel coumarinolignoid alkaloids (indicumines A–B, 1–2) and two new coumarinolignoids (indicumines C–D, 3–4), together with four known coumarins (5–8). Their structures were established on the basis of spectroscopic data. The two novel coumarinolignoid alkaloids shows anti-HBV activities through specifically inhibiting the secretion of HBsAg in HepG2.2.15.