Structural characterization and antioxidant activity of a low-molecular polysaccharide from Dendrobium huoshanense |
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| Institution: | 1. College of Food Science and Technology, Yunna Agricultural University, Kunming 650201, China;2. Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;3. Key Laboratory of Pu-er Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming 650201, China;1. Department of Food Science, University of Guelph, Guelph, ON, Canada N1G 2W1;2. Guelph Food Research Centre, Agriculture and Agri-Food Canada, Guelph, ON, Canada N1G 5C9;3. State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, Jiangxi, China;4. Glyn O. Phillips Hydrocolloid Research Centre, Glynd?r University, Wrexham LL11 2AW, UK;5. Phillips Hydrocolloids Research Ltd., 45 Old Bond Street, London W1S 4QT, UK;1. Guangdong Food and Drug Vocational College, Guangzhou, Guangdong, 510520, PR China;2. School of Pharmaceutical Science, and Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, PR China;3. Affiliated Huai’an Hospital of Xuzhou Medical University, Huai’an, Jiangsu, 223001, PR China;4. Jiangsu Key Laboratory of Regional Resource Exploitation and Medicinal Research, Huai’an, Jiangsu, 223003, PR China;5. Dongguan Mathematical Engineering Academy of Chinese Medicine and Guangzhou University of Chinese Medicine, Dongguan, Guangdong, 523808, PR China;1. School of Chemistry and Chemical Engineering, Guangxi University, 100 Daxue Road, Nanning 530004, Guangxi, P. R. China;2. Guangxi Colleges and Universities Key Laboratory of Applied Chemistry Technology and Resource Development, Guangxi University, 100 Daxue Road, Nanning, Guangxi, P. R. China;1. College of Biotechnology and Pharmaceutical Engineering, West Anhui University, Lu’an City 237012, China;2. School of Pharmacy, Anhui University of Traditional Chinese Medicine, Hefei 230012, China;3. The Provincial 2011 Collaborative Innovation Center of Anhui-Dendrobium Huoshanense Industrialization Exploitation Collaborative Innovation Center, Lu’an City 237012, China;4. West Anhui Biotechnology Research Center of Natural Medicine and Traditional Chinese Medicine, West Anhui University, Lu’an City 237012, China;5. College of Pharmacy, Anhui Medical University, Hefei 230032, China |
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| Abstract: | The present study aimed at investigating the structural features and antioxidant activities of a polysaccharide fraction (DHP1A) obtained from Dendrobium huoshanense, a precious herb medicine in China. DHP1A mainly consisted of mannose (Man), glucose (Glc) and a trace of galactose (Gal), with a molecular weight of 6700 Da. Its backbone contained (1 → 4)-linked α-D-Glcp, (1 → 6)-linked α-D-Glcp and (1 → 4)-linked β-D-Manp, with a branch of terminal β-D-Galp. The in vitro antioxidant evaluation revealed that DHP1A had a remarkable inhibition effect on the FeCl2-induced lipid peroxidation. Furthermore, DHP1A pretreatment decreased the production of malondialdehyde (MDA), and restored the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx), as well as the level of glutathione (GSH) in the livers of CCl4-treated mice. These results suggested that DHP1A was a potential antioxidant component in D. huoshanense. |
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