| 苦参注射液治疗乙型肝炎性肝硬化疗效及其作用机制研究 |
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| 引用本文： | 暴秀兰,尹桂华.苦参注射液治疗乙型肝炎性肝硬化疗效及其作用机制研究[J].吉林林学院学报,2014(6):780-782. |
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| 作者姓名： | 暴秀兰 尹桂华 |
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| 作者单位： | 北华大学附属医院,吉林吉林132011 |
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| 基金项目： | 吉林省教育厅科学技术研究项目（2013js143）. |
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| 摘 要： | 目的：观察苦参注射液对慢性乙型肝炎性肝硬化的临床效果及其作用机制.方法将58例慢性乙型肝炎性肝硬化患者随机分为观察组和对照组，在一般支持治疗的基础上，观察组加用苦参注射液，治疗8周后，比较两组肝功能、肝纤维化指标.结果观察组肝功能改善显著，肝纤维化减轻，与对照组比较差异均有统计学意义（P〈0.05）.结论在正常治疗基础上加用苦参注射液，有助于肝炎性肝硬化患者的肝功能恢复，有较好的临床效果.其作用机制可能是通过影响外周单核细胞IL-10表达、调节机体促炎抗炎平衡而实现的.
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| 关 键 词： | 苦参注射液 乙型肝炎性肝硬化 IL-10 |
On Effect of Matrine Injection in Treatment of Hepatitis B Cirrhosis and Its Mechanism |
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| Institution: | Bao Xiulan, Ying Guihua (Affiliated Hospital of Beihua University ,Jilin 132011 China) |
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| Abstract: | Objective To observe the clinical effect and its therapeutic mechanism of matrine injection in the treatment of chronic hepatitis B cirrhosis. Method 58 patients with chronic hepatitis B cirrhosis were randomly divided into observation group and control group. Based on the general support therapy,observation group plus matrine injection, comparison of liver function, hepatic fibrosis in two groups after 8 weeks treatment. Results The liver function, liver fibrosis relief were improved in observation group. The control group had significant difference （ P〈0 . 05 ） . Conclusion Combined with Matrine Injection under the normal treatment would contribute to the recovery of liver function in the patients with posthepatitic cirrhosis. Its mechanism is probable by affecting the expression of peripheral mononuclear cell IL-10 and regulating proinflammatory and anti-inflammatory balance of body. |
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| Keywords: | Matrine injection Hepatitis B cirrhosis IL- 10 |
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