A case of mannosidosis in the cat: clinical and histopathological findings

A case of feline mannosidosis is described. The animal was very small for its age (nine months) and showed skeletal defects and severe neurological signs which were first recognized at seven months of age. There was extensive cytoplasmic vacuolation of cells in visceral organs and in the nervous system. The vacuoles were usually empty. This case of mannosidosis in the cat most closely resembles the severe human variant of this disease rather than the bovine disease.