| 丁酸对亚急性瘤胃酸中毒的影响机制研究进展 |
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| 引用本文： | 代鹏,姜雅慧,王之盛. 丁酸对亚急性瘤胃酸中毒的影响机制研究进展[J]. 动物营养学报, 2022, 34(2): 736-744. DOI: 10.3969/j.issn.1006?267x.2022.02.007 |
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| 作者姓名： | 代鹏 姜雅慧 王之盛 |
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| 作者单位： | 四川农业大学动物营养研究所,四川省牛低碳养殖与安全生产高校重点实验室,成都 611130;四川农业大学动物科技学院,成都 611130 |
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| 基金项目： | 国家自然科学基金项目(31802086)。 |
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| 摘 要： | 亚急性瘤胃酸中毒(SARA)作为反刍动物饲养中因营养代谢紊乱而高发的疾病，严重影响了反刍动物的健康和生产。近年来研究发现，丁酸作为瘤胃中主要的挥发性脂肪酸(VFA)，具有调控细胞增殖以及抗炎等作用。本文结合近年研究，从SARA破坏瘤胃屏障功能、诱发炎症反应的机制，重点阐述了丁酸作为信号分子和组蛋白去乙酰化酶抑制剂(HDACIs)识别G蛋白偶联受体(GPRs)，促进组蛋白乙酰化、调控下游信号通路改善瘤胃上皮屏障功能和缓解炎症反应的生理过程，为更进一步研究丁酸对反刍动物SARA中的影响提供参考。
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| 关 键 词： | 丁酸 亚急性瘤胃酸中毒 信号分子 屏障功能 抗炎 |
Research Progress on Effects Mechanism of Butyric Acid on Subacute Ruminal Acidosis |
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| DAI Peng,JIANG Yahui,WANG Zhisheng. Research Progress on Effects Mechanism of Butyric Acid on Subacute Ruminal Acidosis[J]. CHINESE JOURNAL OF ANIMAL NUTRITION, 2022, 34(2): 736-744. DOI: 10.3969/j.issn.1006?267x.2022.02.007 |
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| Authors: | DAI Peng JIANG Yahui WANG Zhisheng |
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| Affiliation: | (Key Laboratory of University in Cattle Low Carbon Breeding and Safety Production in Sichuan Province,Animal Nutrition Institute,Sichuan Agricultural University,Chengdu 611130,China;College of Animal Science and Technology,Sichuan Agricultural University,Chengdu 611130,China) |
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| Abstract: | Subacute ruminal acidosis(SARA)is a disease with high incidence in ruminant rearing due to nutrient metabolism disorder,which seriously affects the health and production of ruminants. In recent years,it has been found that butyric acid,as the main volatile fatty acid(VFA)in the rumen,plays a role in regulating cell proliferation and anti-inflammation. Based on recent studies,this paper focuses on butyric acid as a signal molecule and histone deacetylase inhibitors(HDACIs)to recognize G-protein coupled receptors(GPRs)from the mechanism of rumen barrier function and its induction of inflammatory response,it can promote histone acetylation,regulate downstream signaling pathways to improve rumen epithelial barrier function and alleviate the physiological process of inflammatory response,which provides a reference for further study on the effect of butyric acid on SARA in ruminants.[Chinese Journal of Animal Nutrition,2022,34(2):736-744] |
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| Keywords: | butyric acid subacute ruminal acidosis signal molecule barrier function anti-inflammatory |
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