白头翁皂苷B4对哺乳期犊牛生长性能和血清指标的影响

本试验旨在研究白头翁皂苷B4对哺乳期犊牛生长性能和血清指标的影响.选取60头新生荷斯坦公犊牛,随机分为4组(每组15头),分别饲喂在代乳粉中添加0(C组)、15(A1组)、30(A2组)和45 mg/d(A3组)白头翁皂苷B4的饲粮.试验期56 d,其中预试期14 d,正试期42 d.每2周空腹称重、测量体尺,每日记录...

Effects of Anemoside B4 on Growth Performance and Serum Indices of Sucking Calves

The objective of this experiment was to investigate the effects of anemoside B4 on growth perform?ance and serum indices of sucking calves.In this experiment,sixty newborn Holstein male calves were random?ly divided into 4 groups(15 calves in each group)and fed diets supplemented with 0(group C),15(group A1),30(group A2)and 45(group A3)mg/d anemoside B4 in the milk replacer,respectively.The experi?ment lasted for 56 days,including 14 days of pre?experiment and 42 days of formal experiment.The body weight and size were taken every 2 weeks on an empty stomach,the feed intake and fecal score were recorded every day,and the serum hormone levels,antioxidant and immune indices of calves at 28 and 56 days of age were measured.The results showed as follows:1)dietary anemoside B4 had no significant effects on the body weight and average daily feed intake of sucking calves(P>0.05),the average daily gain of calves in group A3 was significantly higher than that in group C from 14 to 28 days of age(P<0.05),and the feed to gain ratio of calves in groups A2 and A3 was significantly lower than that in group C from 14 to 28 days of age(P<0.05).2)Dietary anemoside B4 had no significant effects on the wither height,body steep length,hip width and heart girth of sucking calves(P>0.05).3)Compared with group C,the fecal score and diarrhea rate of calves in groups A1,A2 and A3 were significantly decreased from 7 to 42 days of age(P<0.05).4)At 28 days of age,the contents of growth hormone(GH)and interleukin?10 in serum and the activities of superoxide dismutase(SOD)and catalase(CAT)in serum of calves in groups A1,A2 and A3 were significantly higher than those in group C(P<0.05),and the contents of malondialdehyde(MDA),interleukin?8 and tumor nec?rosis factor?αin serum were significantly lower than those in group C(P<0.05);the glutathione peroxidase activity and contents of immunoglobulin G(IgG),immunoglobulin A(IgA)and immunoglobulin M(IgM)in serum of calves in groups A2 and A3 were significantly higher than those in group C(P<0.05),and the in?terleukin?6(IL?6)content in serum was significantly lower than that in group C(P<0.05);the insulin?like growth factorⅠ(IGF?Ⅰ)content in serum of calves in group A3 was significantly higher than that in groups C,A1 and A2(P<0.05),and the contents of IgG and IgM in serum were significantly higher than that in group A1(P<0.05).At 56 days of age,there were no significant differences in serum GH,IgG and IgA con?tents among all groups(P>0.05);the IGF?Ⅰcontent and SOD activity in serum of calves in group A3 tended to be significantly higher than those in group C(0.050.05);the serum IGF?Ⅰcontent in group A3 tended to be significantly higher than that in group C(0.05