Cytotoxic prenylated flavonoids from Morus alba |
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| Authors: | Nguyen Tien Dat Phung Thi Xuan Binh Le Thi Phuong Quynh Chau Van Minh Hoang Thanh Huong Jung Joon Lee |
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| Affiliation: | a Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Hanoi, Vietnam;b Institute of Natural Product Chemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Hanoi, Vietnam;c Molecular Cancer Research Center, Korean Institute of Biosciences and Biotechnology, Ochang, South Korea |
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| Abstract: | A phytochemical fractionation of the methanol extract of the Morus alba leaves led to the isolation of eleven flavonoids (1–11). The structure of the new 3′-geranyl-3-prenyl-2′,4′,5,7-tetrahydroxyflavone (1) was elucidated by means of spectroscopic methods. The cytotoxicity of the isolated compounds against human cervical carcinoma HeLa, human breast carcinoma MCF-7, and human hepatocarcinoma Hep3B cells was evaluated. Of note, morusin (9) was the most potent with an IC50 value of 0.64 μM against HeLa cells. |
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| Keywords: | Morus alba Moraceae Prenylated flavonoid Morusin Cytotoxicity |
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