Toxicokinetics and absolute oral bioavailability of melamine in broiler chickens |
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| Authors: | S. Poapolathep N. Klangkaew P. Arreesrisom S. Isariyodom Y. Sugita‐Konishi S. Kumagai A. Poapolathep |
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| Affiliation: | 1. Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand;2. Faculty of Veterinary Technology, Kasetsart University, Bangkok, Thailand;3. Department of Animal Husbandry, Faculty of Agriculture, Kasetsart University, Bangkok, Thailand;4. Department of Food and Life Sciences, Azabu University, Kanagawa, Japan;5. Research Center for Food Safety, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan |
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| Abstract: | The objective of this study was to investigate the toxicokinetic characteristics of melamine in broilers due to the limited information available for livestock. Melamine was then administered to broiler chickens at an intravenous (i.v.) or oral (p.o.) dosage of 5.5 mg/kg of body weight, and plasma samples were collected up to 48 h. The concentration of melamine in each plasma sample was analyzed using liquid chromatography‐tandem mass spectrometry (LC‐MS/MS). Melamine was measurable up to 24 h after i.v. and p.o. administration. A one‐compartment model was developed to describe the toxicokinetics of melamine in broilers. Following i.v. administration, the values for the elimination half‐life (t1/2β), the volume of distribution (Vd), and the clearance (CL) were 4.42 ± 1.02 h, 00.52 ± 0.18 L/kg, and 0.08 ± 0.01 L/h/kg, respectively. The absolute oral bioavailability (F) was 95.63 ± 3.54%. The results suggest that most of the administered melamine is favorably absorbed from the alimentary tract and rapidly cleared by the kidneys in broiler chickens. |
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