Estimating danofloxacin withdrawal time in broiler chickens based on physiologically based pharmacokinetics modeling |
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| Authors: | F. Yang N. Sun Y. M. Liu Z. L. Zeng |
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| Affiliation: | 1. College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, China;2. Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun, China;3. Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing, China;4. College of Veterinary Medicine, South China Agricultural University, Guangzhou, China |
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| Abstract: | In this study, a physiologically based pharmacokinetics (PBPK) model was firstly developed for danofloxacin in healthy broiler chickens after a single oral administration at 5 mg/kg bw. Then, the model extrapolation from healthy chickens to those infected with Pasteurella multocidaones was performed. The healthy model was validated through a comparison of predicted and previously published concentrations, which indicated that the healthy PBPK model had good predictive ability in plasma, lung, muscle, liver, and kidney, especially at the later sampling time points. Multiple dosing of administration was incorporated into the healthy and infected models. In addition, a Monte Carlo simulation (MCS) included 1000 iterations was further incorporated into both models to predict the withdrawal times of danofloxacin in healthy and infected chickens, which were estimated to be 3 and 2 days, respectively. |
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