Serum vascular endothelial growth factor in dogs with soft tissue sarcomas |
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| Authors: | G. Fernandes de Queiroz,M. Lúcia Zaidan Dagli,S. Aparecida Meira,J. Maria Matera |
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| Affiliation: | 1. Department of Animal Sciences, Federal Rural University of the Semi‐Arid, , Mossoró, RN, Brazil;2. Department of Pathology, School of Veterinary Medicine and Animal Science, University of Sao Paulo, , S?o Paulo, SP, Brazil;3. Department of Statistics, Institute of Earth Sciences, Federal University of Mato Grosso, , Cuiabá, MT, Brazil;4. Department of Surgery, School of Veterinary Medicine and Animal Science, University of Sao Paulo, , S?o Paulo, SP, Brazil |
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| Abstract: | This work aimed to evaluate serum vascular endothelial growth factor (VEGF) in 25 dogs with soft tissue sarcoma, and in 30 healthy dogs. Blood was collected once time from the control animals and three times, in the same way, from animals with sarcoma. Blood count was performed in the blood collected, and serum VEGF was measured by enzyme‐linked immunosorbent assay quantitative method. Serum VEGF in control animals was similar to patients with soft tissue sarcoma. There was a reduction in serum VEGF after the sarcoma resection. There was positive correlation between serum VEGF and neutrophil counts, and negative between VEGF and hemoglobin content in animals with sarcoma. Animals with hemangiopericytoma showed higher serum VEGF levels compared to the patients with malignant peripheral nerve sheath. Circulating blood cells can contribute to elevate VEGF serum concentrations in dogs with soft tissue sarcomas and a possible role of VEGF in the angiogenesis of these tumors. |
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| Keywords: | growth factors oncology serum marker small animal surgical oncology |
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