| 寄生虫抗肿瘤研究进展 |
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| 引用本文： | 邓柏林,张西臣,高步先,张国才,李建华.寄生虫抗肿瘤研究进展[J].中国兽医寄生虫病,2008,16(3):43-46. |
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| 作者姓名： | 邓柏林 张西臣 高步先 张国才 李建华 |
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| 作者单位： | 1. 北京军区疾病预防控制中心,北京,100042
2. 吉林大学畜牧兽医学院,长春,130062 |
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| 基金项目： | 吉林省科技厅应用基础研究项目
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国家重点基础研究发展计划(973计划) |
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| 摘 要： | 虽然旋毛虫抗肿瘤的分子机制仍不清楚，但旋毛虫具有抗肿瘤的效应却已被许多实验所证实。小鼠感染旋毛虫后对肿瘤细胞在体内的增殖或对移植进体内的肿瘤生长的抑制作用，其可能的机理是旋毛虫感染机体后激发宿主免疫网络系统促使机体产生多种免疫活性细胞因子，发挥特异性和非特异性抗肿瘤免疫功能；或者是由于寄生虫本身就具有能够分泌排泄一些抗肿瘤活性物质而发挥抗肿瘤效应；或者是由于寄生虫感染诱导肿瘤的基因表达发生变化而产生了抗肿瘤的效应。
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| 关 键 词： | 旋毛虫 抗肿瘤 进展 |
| 文章编号： | 1005-0868(2008)03-0043-04 |
| 修稿时间： | 2008年1月14日 |
ADVANCE ON ANTITUMOR EFFECT OF PARASITES |
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| DENG Bo-lin,ZHANG Xi-chen,GAO Bu-xian,ZHANG Guo-cai,LI Jian-hua.ADVANCE ON ANTITUMOR EFFECT OF PARASITES[J].Chinese Journal of Veterinary Parasitology,2008,16(3):43-46. |
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| Authors: | DENG Bo-lin ZHANG Xi-chen GAO Bu-xian ZHANG Guo-cai LI Jian-hua |
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| Institution: | DENG Bo-lin , ZHANG Xi-chen, GAO Bu-xian , ZHANG Guo-cai, LI Jian-hua ( 1. Center for Disease Prevention and Control of Beijing Military Area Command, Beijing 100042, China; 2. College of Animal Science and Veterinary Medicine in University of Jilin, Changchun 130062, China) |
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| Abstract: | Although very little is known about Anti-tumor molecular mechanisms of Trichinella spiralis, it has been verified in many experiments. Studies of mice infected Trichinella spiralis demonstrated that this parasite has an effect of inhibition to tumour cell growth. These possible mechanisms are involved in that Trichinella spiralis infection induced the host immunological network to produce many immunological activity cytokines, which play a im- portant role on specific and nonspecific immunity ; The parasite itself can excrete some antineoplasmic activity compounds that resulted in Anti-tumor effect; After the parasitic infected the gene expression change of tumor cell was induced to produce Anti-tumor effects. |
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| Keywords: | Trichinella spiralis anti-tumor advance |
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