The activity of triclabendazole against immature and adult Fasciola hepatica infections in sheep |
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| Authors: | M G SMEAL C A HALL |
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| Institution: | Department of Agriculture, New South Wales Veterinary Research Station, Glenfield, New South Wales 2167 |
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| Abstract: | SUMMARY The efficiency of a new benzimidazole anthelmintic, triclabendazole, was tested against cumulative infections with Fasciola hepatica aged 1 to 12 weeks in sheep and compared with that of rafoxanide. At 10 mg/kg, triclabendazole was 99% effective in eliminating both immature and adult flukes. At a lower dose rate of 5 mg/kg, triclabendazole was highly effective against adults and significantly reduced the number of early immature flukes with an 87% overall reduction of fluke burden. Rafoxanide at 7.5 mg/kg showed high efficiency against adult fluke, but its effect on immatures was not significant, and overall efficiency was 64%. |
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