Two New Cytotoxic Indole Alkaloids from a Deep-Sea Sediment Derived Metagenomic Clone |
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| Authors: | Xia Yan Xi-Xiang Tang Lin Chen Zhi-Wei Yi Mei-Juan Fang Zhen Wu Ying-Kun Qiu |
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| Affiliation: | 1.Key Laboratory for Chemical Biology of Fujian Province, School of Pharmaceutical Sciences, Xiamen University, South Xiang-An Road, Xiamen 361102, China; E-Mails: (X.Y.); (L.C.); (M.-J.F.);2.Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography State Oceanic Administration, Xiamen 361005, China; E-Mails: (X.-X.T.); (Z.-W.Y.) |
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| Abstract: | Two new indole alkaloids, metagenetriindole A (1) and metagenebiindole A (2), were identified from deep-sea sediment metagenomic clone derived Escherichia coli fermentation broth. The structures of new compounds were elucidated by spectroscopic methods. The two new indole alkaloids demonstrated moderately cytotoxic activity against CNE2, Bel7402 and HT1080 cancer cell lines in vitro. |
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| Keywords: | deep-sea sediment metagenomic clone indole alkaloids metagenetriindole A metagenebiindole A cytotoxicity |
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