Antibody-dependent mechanisms of immunity against migrating larvae of Trichinella spiralis

Normal rat peritoneal exudate cells adhere to new-born Trichinella spiralis larvae in the presence of specific antibodies produced during the course of an oral infection. After 24 hours incubation with the peritoneal cells and antibodies most of the larvae were killed. Heated immune serum had less activity. With normal serum no adherence was observed. In order to investigate the influence of antibodies on new-born larvae in vivo, larvae were pre-treated in vitro with immune serum and then inoculated intravenously into normal mice. After 30 days the yield of normal larvae was 50% of the number recovered in a control group infected with non-treated new-born larvae.