| 农药中间体2-溴-4-氨基吡啶的合成研究 |
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| 引用本文： | 方永勤,蒋彬峰.农药中间体2-溴-4-氨基吡啶的合成研究[J].安徽农业科学,2009,37(11):4861-4863. |
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| 作者姓名： | 方永勤 蒋彬峰 |
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| 作者单位： | 江苏工业学院精细化工研究所,江苏常州,213164;江苏工业学院精细化工研究所,江苏常州,213164 |
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| 基金项目： | 常州精细化工研究所项目资助 |
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| 摘 要： | 目的]研究农药中间体2-溴-4-氨基吡啶的合成。方法]以2-溴吡啶为原料,经氧化、硝化“一锅法”制得2-溴-4-硝基吡啶-N-氧化物,再经铁粉还原制得2-溴-4-氨基吡啶。结果]结果表明,2-溴吡啶-N-氧化物（Ⅰ）、2-溴-4-硝基吡啶-N-氧化物（Ⅱ）和2-溴4-氨基吡啶（Ⅲ）合成的总产率为71.2%,结构经IR1、H NMR确证。该方法具有工艺简单、收率高和对设备要求低的优点。结论]该研究结果为农药中间体的合成实现工业化提供理论指导。
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| 关 键 词： | 2-溴吡啶氮氧化物 2-溴-4-硝基氮氧化物 2-溴-4-氨基吡啶 氧化 |
Study on Synthesis of 2-Bromo-4-aminopyridine |
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| FANG Yong-qin et al.Study on Synthesis of 2-Bromo-4-aminopyridine[J].Journal of Anhui Agricultural Sciences,2009,37(11):4861-4863. |
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| Authors: | FANG Yong-qin |
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| Institution: | FANG Yong-qin et al(The Institute of Fine Chemical Engineering,Jiangsu Polytechnic University,Changzhou,Jiangsu 213164) |
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| Abstract: | Objective] The purpose of this research was to study the synthesis of 2-Bromo-4-Aminopyridine.Method] 2-Bromo-4-aminopyridine was prepared with 2-bromopyridine as raw materials by oxidation,nitration and reduction.Result]The results indicated that total yield of Ⅲ amounted to 71.2%.Structures of the products were confirmed by IR and 1H NMR.This method had the excellence of simple craftwork,high yield and low demand for equipment.Conclusion]This study will provide theoretical guidance for realizing industrialization of the synthesis of pesticide intermediate. |
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| Keywords: | 2-bromopyridine-N-oxid 2-bromo-4-nitropyridine-N-oxide 2-bromo-4-aminopyridine Oxidation |
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