Inheritance of equine sarcoid disease in Franches-Montagnes horses |
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| Authors: | Garance Christen Vinzenz Gerber Gaudenz Dolf Dominique Burger Christoph Koch |
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| Affiliation: | 1. Swiss Institute of Equine Medicine, University of Berne and ALP-Haras, Länggasstrasse 124, Postfach 8466, CH-3001 Berne, Switzerland;2. Institute of Genetics, University of Berne, Bremgartenstrasse 109a, Postfach 8466, CH-3001 Berne, Switzerland;1. Laboratoire Image Ville Environnement UMR 7362 CNRS/UdS, Faculté de Géographie et Aménagement, 3, rue de l’Argonne, 67000, Strasbourg, France.;2. Chair of Production and Logistics, Georg August Universität Göttingen (D), Platz der Göttinger Sieben 3, 37073, Göttingen, Germany.;1. College of Economics and Management, Northeast Agricultural University, Harbin 150030, China;2. College of Economics and Management, Northeast Forest University, Harbin 150040, China;1. University of Bristol, School of Veterinary Sciences, Langford, Bristol BS40 7DU, UK;2. Veterinary Laboratory, The Donkey Sanctuary, Sidmouth, Devon EX10 0NU, UK;1. Departments of Veterinary Clinical Sciences, Iowa State University, Ames, IA;2. Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, IA;3. Veterinary Pathology, Iowa State University, Ames, IA |
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| Abstract: | The mode of inheritance for susceptibility to equine sarcoid disease (ES) remains unknown. The objectives of this study were to analyse a large sample of the Franches-Montagnes (FM) horse population and investigate the heritability and mode of inheritance for susceptibility to ES. Horses were clinically examined for the presence of sarcoid tumours. A standardized examination protocol and client questionnaire were used and a pedigree- and subsequent segregation-analysis for the ES trait performed. To investigate the mode of inheritance, five models were evaluated and compared in a hierarchical way.The analyses reveal that variation in susceptibility to ES is best explained by a model incorporating polygenic variation. The possible effect of a major gene, such as specific equine leukocyte antigen alleles, is unlikely, but cannot be ruled-out entirely. The heritability of the phenotype on the observation scale for the trait ‘affected with ES’ was estimated to be 8%. A corrected value for the heritability on a liability scale was estimated at 21% and it is therefore possible to estimate breeding values for ES. The arguments against the practical implementation of an estimated breeding value in a multifactorial condition like ES are discussed. |
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| Keywords: | Horse Sarcoid Heritability Segregation analysis Breeding |
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