| 两株1型鸭甲肝病毒山东分离株的鉴定与致病性分析 |
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| 引用本文： | 王宇飞,孙伟,陈佶慧,刘芹防,滕巧泱,杨健美,苑纯秀,李泽君,李雪松,关平原. 两株1型鸭甲肝病毒山东分离株的鉴定与致病性分析[J]. 中国动物传染病学报, 2021, 0(1): 26-30 |
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| 作者姓名： | 王宇飞 孙伟 陈佶慧 刘芹防 滕巧泱 杨健美 苑纯秀 李泽君 李雪松 关平原 |
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| 作者单位： | 内蒙古农业大学兽医学院;中国农业科学院上海兽医研究所;中国农业大学动物医学院 |
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| 基金项目： | 国家自然科学基金项目(31702237,31771000);上海市自然科学基金项目(17ZR1437400);国家重点研发计划“家禽重要疫病诊断与检测新技术研究”(2016YFD0500800);上海科委创新行动计划农业项目(17391901700)。 |
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| 摘 要： | 鸭病毒性肝炎(DVH)是危害雏鸭的一种急性高度致死性传染病,引发DVH的主要病原体为鸭甲肝病毒(DHAV),其中1型鸭肝炎病毒在中国各省流行最广.本研究于2018年从山东某养鸭场的病料中分离得到两株DHAV,经分子生物学鉴定、序列比对和进化树分析,鉴定引起雏鸭患病的病原体为DHAV-1.经过纯化后,对SPF雏鸭进行致病...
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| 关 键 词： | 鸭肝炎病毒 DHAV-1 鉴定 致病性 |
Identification and Pathogenicity of Two Duck Hepatitis A Virus Type 1 Isolated in Shandong,China |
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| WANG Yufei,SUN Wei,CHEN Jihui,LIU Qinfang,TENG Qiaoyang,YANG Jianmei,YUAN Chunxiu,LI Zejun,LI Xuesong,GUAN Pingyuan. Identification and Pathogenicity of Two Duck Hepatitis A Virus Type 1 Isolated in Shandong,China[J]. Chinese Journal of Animal Infectious Diseases, 2021, 0(1): 26-30 |
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| Authors: | WANG Yufei SUN Wei CHEN Jihui LIU Qinfang TENG Qiaoyang YANG Jianmei YUAN Chunxiu LI Zejun LI Xuesong GUAN Pingyuan |
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| Affiliation: | (College of Veterinary Medicine,Inner Mongolia Agricultural University,Hohhot 010018,China;Shanghai Veterinary Research Institute,CAAS,Shanghai 200241,China;College of Veterinary Medicine,China Agricultural University,Beijing 100193,China) |
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| Abstract: | Duck viral hepatitis(DVH)is a highly contagious and fatal disease in ducklings.Duck hepatitis A virus(DHAV)is a major etiological agent and DHAV-1 is widely prevalent in many provinces of China.Two strains of DHAV-1 were isolated in 2018 from a sick duck farm in Shandong province and characterized for their molecular biology,sequences,phylogenetic tree and pathogenicity.The isolated two strains were inoculated into duck embryos and virus titers were determined with a fluorescence assay.Then,SPF ducklings were infected with these two strains and pathological changes were observed in tissues.As a result,SD37 strain caused 100%deaths and SD63 strain had 12.5%mortality.The results of the present study provided a basis for future research on molecular epidemiology and control of DHAV-1 in China. |
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| Keywords: | Duck hepatitis virus DHAV-1 identification pathogenicity |
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