Antiproliferative activity of Citrus juices and HPLC evaluation of their flavonoid composition |
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| Authors: | Camarda Lorenzo Di Stefano Vita Del Bosco Sergio Fatta Schillaci Domenico |
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| Affiliation: | Dipartimento di Chimica e Tecnologie Farmaceutiche, Università degli Studi di Palermo, via Archirafi 32, 90123, Palermo, Italy. camarnat@unipa.it |
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| Abstract: | The antiproliferative activity of fresh fruit juices extracted from Citrus sinensis (cv. Washington Navel and cv. Sanguinello), C. deliciosa cv. Avana, C. clementina cv. Nules, C. aurantium subsp. myrtifolia , was evaluated against K562 (human chronic myelogenous leukemia), HL-60 (human leukemia) and MCF-7 (human breast adenocarcinoma) cell lines. All the juices tested showed antiproliferative activity. Moreover, the pattern of the main flavanone compounds in the juices has been determined by HPLC analysis. |
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| Keywords: | Antiproliferative activity Citrus species Flavanones |
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