| 黏菌素对小鼠神经传导速率及运动单元动作电位的影响 |
| |
| 引用本文： | 李继昌,代重山,马晶,蒋红,李睿,张德显,林巍.黏菌素对小鼠神经传导速率及运动单元动作电位的影响[J].东北农业大学学报,2013(3):1-4. |
| |
| 作者姓名： | 李继昌 代重山 马晶 蒋红 李睿 张德显 林巍 |
| |
| 作者单位： | 东北农业大学动物医学学院;东北农业大学校医院;沈阳农业大学畜牧兽医学院 |
| |
| 基金项目： | 黑龙江省教育厅科学技术研究项目(12521043) |
| |
| 摘 要： | 为探讨黏菌素对小鼠感觉神经传导速率(SNCV)、运动神经传导速率(MNCV)及运动单元动作电位(MUAP)的影响,对50只昆明系小鼠单次尾静脉注射硫酸黏菌素7.5 mg.kg-1,每12 h 1次,连续给药7 d。分别于第1、3、7、14天(以初次给药当天为第1天计)测定小鼠坐骨神经SNCV、MNCV及MUAP,并对腓肠肌进行病理学检查。结果表明,与对照组相比,黏菌素给药3 d后,SNCV降低至(30.67±1.15)m.s-(1P0.05)。给药7 d后,神经传导速率(NCV)显著降低,MNCV降低至(24.47±0.41)m.s-(1P0.05),SNCV降低至(29.67±2.89)m.s-(1P0.05);此外,腓肠肌MUAP降低至(0.26±0.0153)mV(P0.05),运动单元动作电位持续时间(MUAPD)降低至(0.3±0.046)s(P0.01)。表明黏菌素可影响小鼠的神经感觉及运动功能,并可导致小鼠肌肉无力。SNCV变化较为敏感,可作为黏菌素诱发神经毒性的早期诊断指标。
|
| 关 键 词： | 黏菌素 小鼠 SNCV MNCV MUAP |
Effect of colistin on nerve conduction velocity and motor unit action potential in mice |
| |
| LI Jichang,DAI Chongshan,MA Jing,JIANG Hong,LI Rui,ZHANG Dexian,LIN Wei.Effect of colistin on nerve conduction velocity and motor unit action potential in mice[J].Journal of Northeast Agricultural University,2013(3):1-4. |
| |
| Authors: | LI Jichang DAI Chongshan MA Jing JIANG Hong LI Rui ZHANG Dexian LIN Wei |
| |
| Institution: | 1(1.School of Veterinary Medicines,Northeast Agricultural University,Harbin 150030,China;2.Hospital,Northeast Agricultural University,Harbin 150030,China;3.School of Animal Husbandry and Veterinary Medicine,Shenyang Agricultural University,Shenyang 110866,China) |
| |
| Abstract: | To investigate the toxic effect of colistin on sensory and motor nerve conduction velocities(SNCV and MNCV),motor unite action potentials(MUAP) and its duration(MUAPD) in adult mice,50 mice were intravenously given 7.5 mg.kg-1 colistin in normal saline via tail vain twice a day for 7 days.On days 1,3,7 and 14 of the experiment,SNCV-,MNCV-,MUAP-and MUAPD-values were determined.The results showed that,compared with the control,after colistin was given for 3 d,SNCV was significantly decreased to 30.67±1.15 m.s-1(P<0.05);After colistin was given for 7 d,MNCV and SNCV were significantly decreased to(24.47 ± 0.41)(P<0.05) and(29.67 ± 2.89) m.s-1(P<0.05),respectively.In addition,MUAP and MUAPD of gastrocnemius muscle was significantly decreased to(0.26±0.015) mV(P<0.05) and(0.3±0.046) s(P<0.01),respectively.The results revealed that colistin decreased the motor and sensory functions,and caused muscle weakness of mice.The SNCV was more sensitive than others,and maybe helpful to detect colistin induced peripheral neurotoxicity. |
| |
| Keywords: | colistin mice SNCV MNCV MUAP |
| 本文献已被 CNKI 等数据库收录！ |
|
