| 影响鸡脂肪肝出血综合征的因素及“多重打击”学说 |
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| 引用本文： | 张弥,涂闻君,张奇,江莎.影响鸡脂肪肝出血综合征的因素及“多重打击”学说[J].畜牧兽医学报,2022,53(8):2453-2469. |
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| 作者姓名： | 张弥 涂闻君 张奇 江莎 |
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| 作者单位： | 1. 西南大学动物医学院 动物健康与动物性食品安全国际合作联合实验室, 重庆 400715;2. 西南大学 医学研究院免疫学研究中心, 重庆 402460 |
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| 基金项目： | 国家自然科学基金(31702307)； |
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| 摘 要： | 鸡脂肪肝出血综合征（fatty liver hemorrhagic syndrome，FLHS）是笼养鸡非感染性死亡的主要原因之一，以肝组织质脆、破裂出血、突然死亡为主要特征。鸡由于其生理特性较哺乳动物更易形成FLHS，但鸡FLHS发病机制尚未明确。本文将从FLHS疾病发生的多重影响因素如遗传、营养、激素、环境、肠道微生物等方面进行阐述，列举和对比研究人员通过改变鸡饲粮成分或使用激素等构建FLHS模型的方法，提出“多重打击”学说的发病机制，以期为鸡FLHS研究提供一定的参考。
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| 关 键 词： | 鸡脂肪肝出血综合征 影响因素 模型 '多重打击'学说 |
| 收稿时间： | 2021-09-17 |
The Influencing Factors and the Multiple-hit Pathogenesis of Chicken Fatty Liver Hemorrhagic Syndrome |
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| ZHANG Mi,TU Wenjun,ZHANG Qi,JIANG Sha.The Influencing Factors and the Multiple-hit Pathogenesis of Chicken Fatty Liver Hemorrhagic Syndrome[J].Acta Veterinaria et Zootechnica Sinica,2022,53(8):2453-2469. |
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| Authors: | ZHANG Mi TU Wenjun ZHANG Qi JIANG Sha |
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| Institution: | 1. Joint International Research Laboratory of Animal Health and Animal Food Safety, College of Veterinary Medicine, Southwest University, Chongqing 400715, China;2. Immunology Research Center, Medical Research Institute, Southwest University, Chongqing 402460, China |
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| Abstract: | Fatty liver hemorrhagic syndrome (FLHS) is one of the main causes of noninfectious death in cage chickens. It is characterized by fragile liver, rupture bleeding and sudden death. Chicken is easier to form FLHS than mammals because of its physiological characteristics,but the pathogenesis of chicken FLHS is not clear. This paper will elaborate the multiple influencing factors of FLHS disease, such as genetics, nutrition, hormones, environment and intestinal microorganisms. Enumerating and comparing the way of structuring FLHS model by changing diet composition or hormones, and putting forward the pathogenesis of "the multiple-hit" pathogenesis in order to provide a reference for further study of chicken FLHS. |
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| Keywords: | chicken fatty liver hemorrhagic syndrome influencing factors models the multiple-hit pathogenesis |
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