Quorum sensing as a target for developing control strategies for the plant pathogen <Emphasis Type="Italic">Pectobacterium</Emphasis> |
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Authors: | Denis Faure Yves Dessaux |
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Institution: | (1) Institut des Sciences du Végétal, CNRS, Avenue de la terrasse, 91198 Gif-sur-Yvette Cedex, France |
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Abstract: | Quorum sensing is a regulatory mechanism that connects gene expression to cell density in bacteria. Amongst proteobacteria,
numerous functions are regulated in this way, including pathogenicity in the Enterobacteriaceae genus Pectobacterium. In Pectobacterium, the signalling molecules involved in this regulatory process belong to the N-acyl-homoserine lactone class. Over the last
6 years, various studies have shown that these signal molecules could be degraded by other bacteria or by plant and animal
cells, opening the path to innovative biocontrol strategies. This review explores the various determinants of pathogenicity
in Pectobacterium and describes approaches that have been developed to quench the quorum-sensing-dependent pathogenicity in Pectobacterium. These approaches range from signal degradation by physicochemical constraints to the identification of signal-sensing inhibitors
and from the identification of enzymes degrading acyl-homoserine lactones to the construction of transgenic plants tolerant
to Pectobacterium. |
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Keywords: | Erwinia Pectobacterium N-acyl-homoserine lactone Quorum Quenching Virulence |
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