Lokivetmab improved pruritus in a dog with cutaneous epitheliotropic lymphoma |
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| Authors: | Kiyohiko INAI Keita KITAGAWA Mami MURAKAMI Toshiroh IWASAKI |
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| Institution: | 1)Sakura Animal Hospital, 5-3-1 Kasuga, Toyonaka, Osaka 560-0052, Japan;2)Department of Comparative Medicine and Integrated Biology, College of Veterinary Medicine, Michigan State University, 736 Wilson Rd, East Lansing, MI 48824, USA;3)Joint Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan;4)Pet Skin Clinic, 59-5 Fukaehama, Higashinada, Kobe, Hyogo 658-0023, Japan |
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| Abstract: | A 13-year-old spayed female Cavalier King Charles Spaniel presented with chronic swelling and pruritus on the palmar aspect of the left forepaw and on the tail. Cutaneous epitheliotropic lymphoma (CEL) was diagnosed by histopathology and immunocytochemistry. Prednisolone was initially used alone as an alternative treatment for CEL. Despite long-term corticosteroid therapy, the patient’s physiological (pruritus) and dermatological signs (alopecia, erythema, erosion, and ulceration with crust) progressed and showed no evidence of improvement. To address the worsening condition of pruritus, lokivetmab was started in combination with prednisolone. Once on lokivetmab, the pruritus steadily improved and was effective in resolving and maintaining remission. Further investigation on the critical role of IL-31 in the pruritus pathway of dogs with CEL is required. |
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| Keywords: | cutaneous epitheliotropic lymphoma interleukin 31 (IL-31) lokivetmab pruritus |
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